Role of secretoglobin 3A2 in lung development.

ABSTRACT:

Rationale

Secretoglobin 3A2 (SCGB3A2) was originally identified as a downstream target in lung for the homeodomain transcription factor NKX2-1, whose null mutation resulted in severely hypoplastic lungs. A very low level of SCGB3A2 is expressed in lungs at Embryonic Day (E) 11.5 during mouse development, which markedly increases by E16.5, the time when lung undergoes dramatic morphologic changes, suggesting that SCGB3A2 may be involved in lung development in addition to a known role in lung inflammation.

Objectives

To determine whether SCGB3A2 plays a role in lung development.

Methods

To assess a potential role for SCGB3A2 during early lung development, wild-type and Nkx2-1-null fetal lungs of early developmental stages were subjected to ex vivo organ culture in the p

SUBMITTER: Kurotani R 

PROVIDER: S-EPMC2542440 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature