Nasal ventilation alters mesenchymal cell turnover and improves alveolarization in preterm lambs.

ABSTRACT:

Rationale

Bronchopulmonary dysplasia (BPD) is a frequent cause of morbidity in preterm infants that is characterized by prolonged need for ventilatory support in an intensive care environment. BPD is characterized histopathologically by persistently thick, cellular distal airspace walls. In normally developing lungs, by comparison, remodeling of the immature parenchymal architecture is characterized by thinning of the future alveolar walls, a process predicated on cell loss through apoptosis.

Objectives

We hypothesized that minimizing lung injury, using high-frequency nasal ventilation to provide positive distending pressure with minimal assisted tidal volume displacement, would increase apoptosis and decrease proliferation among mesenchymal cells in the distal airspace wall

SUBMITTER: Reyburn B 

PROVIDER: S-EPMC2542442 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature