Subpopulations of equine infectious anemia virus Rev coexist in vivo and differ in phenotype.

ABSTRACT: Lentiviruses exist in vivo as a population of related, nonidentical genotypes, commonly referred to as quasispecies. The quasispecies structure is characteristic of complex adaptive systems and contributes to the high rate of evolution in lentiviruses that confounds efforts to develop effective vaccines and antiviral therapies. Here, we describe analyses of genetic data from longitudinal studies of genetic variation in a lentivirus regulatory protein, Rev, over the course of disease in ponies experimentally infected with equine infectious anemia virus. As observed with other lentivirus data, the Rev variants exhibited a quasispecies character. Phylogenetic and partition analyses suggested that the Rev quasispecies comprised two distinct subpopulations that coexisted during infection. One s

SUBMITTER: Baccam P 

PROVIDER: S-EPMC254257 | biostudies-literature | 2003 Nov

REPOSITORIES: biostudies-literature