Expression and adhesion profiles of SynCAM molecules indicate distinct neuronal functions.

ABSTRACT: Cell-cell interactions through adhesion molecules play key roles in the development of the nervous system. Synaptic cell adhesion molecules (SynCAMs) comprise a group of four immunoglobulin (Ig) superfamily members that mediate adhesion and are prominently expressed in the brain. Although SynCAMs have been implicated in the differentiation of neurons, there has been no comprehensive analysis of their expression patterns. Here we examine the spatiotemporal expression patterns of SynCAMs by using reverse transcriptase-polymerase chain reaction, in situ hybridization, and immunohistological techniques. SynCAMs 1-4 are widely expressed throughout the developing and adult central nervous system. They are prominently expressed in neurons throughout the brain and are present in both excitatory an

SUBMITTER: Thomas LA 

PROVIDER: S-EPMC2543944 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature