Minimally invasive neuroradiologic model of preclinical transient middle cerebral artery occlusion in canines.

ABSTRACT: Stroke is currently the third leading cause of death in the United States, with approximately 780,000 Americans affected by a new or recurring stroke each year. Although a variety of therapeutic approaches have shown promise in small-animal models of stroke, the vast majority of clinical trials to test the efficacy of such modalities have failed. To bridge the translational gap between laboratory and clinical research, we developed a preclinical model of acute ischemic stroke in dogs. Using a minimally invasive endovascular approach, a platinum coil was intravascularly guided through the vertebrobasilar system under C-arm fluoroscopy to occlude the M1 segment of the middle cerebral artery (MCA) for 1 h. The approach included femoral artery catheterization to access the MCA and therefore el

SUBMITTER: Rink C 

PROVIDER: S-EPMC2544585 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature