Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.

ABSTRACT:

Background

Gastrointestinal cancer, such as gastric, colon and rectal cancer, is a major medical and economic burden worldwide. However, the exact mechanism of gastrointestinal cancer development still remains unclear. RAS genes have been elucidated as major participants in the development and progression of a series of human tumours and the single nucleotide polymorphism at H-RAS cDNA position 81 was demonstrated to contribute to the risks of bladder, oral and thyroid carcinoma. Therefore, we hypothesized that this polymorphisms in H-RAS could influence susceptibility to gastrointestinal cancer as well, and we conducted this study to test the hypothesis in Chinese population.

Methods

A population based case-control study, including 296 cases with gastrointestinal cancer and

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC2546424 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature