Characterization of an outer membrane protein of Salmonella enterica serovar typhimurium that confers protection against typhoid.

ABSTRACT: Typhoid caused by Salmonella enterica serovar Typhi remains a major health concern worldwide. The emergence of multidrug-resistant strains of Salmonella with increased virulence, communicability, and survivability leading to increased morbidity and mortality has further complicated its management. Currently available vaccines for typhoid have less-than-desired efficacy and certain unacceptable side effects, making it pertinent to search for new immunogens suitable for vaccine formulation. The outer membrane proteins (OMPs) of Salmonella have been considered possible candidates for conferring protection against typhoid. OMPs interface the cell with the environment, thus representing important virulence factors with a significant role in the pathobiology of gram-negative bacteria and bacteri

SUBMITTER: Hamid N 

PROVIDER: S-EPMC2546666 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature