The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis.

ABSTRACT: In Bacillus anthracis, the novel type III pantothenate kinase (PanK(Ba); encoded by coaX) catalyzes the first committed step in coenzyme A biosynthesis. We have demonstrated by analyzing the growth characteristics of a conditional coaX mutant that PanK(Ba) is an essential enzyme, thus contributing to its validation as a new antimicrobial target.

SUBMITTER: Paige C 

PROVIDER: S-EPMC2546792 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature