Genomic analysis reveals age-dependent innate immune responses to severe acute respiratory syndrome coronavirus.

ABSTRACT: The relationship between immunosenescence and the host response to virus infection is poorly understood at the molecular level. Two different patterns of pulmonary host responses to virus were observed when gene expression profiles from severe acute respiratory syndrome coronavirus (SARS-CoV)-infected young mice that show minimal disease were compared to those from SARS-CoV-infected aged mice that develop pneumonitis. In young mice, genes related to cellular development, cell growth, and cell cycle were downregulated during peak viral replication, and these transcripts returned to basal levels as virus was cleared. In contrast, aged mice had a greater number of upregulated immune response and cell-to-cell signaling genes, and the expression of many genes was sustained even after viral clea

SUBMITTER: Baas T 

PROVIDER: S-EPMC2546950 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature