A gene signature-based approach identifies mTOR as a regulator of p73.

ABSTRACT: Although genomic technologies have advanced the characterization of gene regulatory networks downstream of transcription factors, the identification of pathways upstream of these transcription factors has been more challenging. In this study we present a gene signature-based approach for connecting signaling pathways to transcription factors, as exemplified by p73. We generated a p73 gene signature by integrating whole-genome chromatin immunoprecipitation and expression profiling. The p73 signature was linked to corresponding signatures produced by drug candidates, using the in silico Connectivity Map resource, to identify drugs that would induce p73 activity. Of the pharmaceutical agents identified, there was enrichment for direct or indirect inhibitors of mammalian Target of Rapamycin (m

SUBMITTER: Rosenbluth JM 

PROVIDER: S-EPMC2547001 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature