Dynamics of glycolytic regulation during adaptation of Saccharomyces cerevisiae to fermentative metabolism.

ABSTRACT: The ability of baker's yeast (Saccharomyces cerevisiae) to rapidly increase its glycolytic flux upon a switch from respiratory to fermentative sugar metabolism is an important characteristic for many of its multiple industrial applications. An increased glycolytic flux can be achieved by an increase in the glycolytic enzyme capacities (V(max)) and/or by changes in the concentrations of low-molecular-weight substrates, products, and effectors. The goal of the present study was to understand the time-dependent, multilevel regulation of glycolytic enzymes during a switch from fully respiratory conditions to fully fermentative conditions. The switch from glucose-limited aerobic chemostat growth to full anaerobiosis and glucose excess resulted in rapid acceleration of fermentative metabolism. A

SUBMITTER: van den Brink J 

PROVIDER: S-EPMC2547023 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature