Sleep loss activates cellular inflammatory signaling.

ABSTRACT:

Background

Accumulating evidence suggests that sleep disturbance is associated with inflammation and related disorders including cardiovascular disease, arthritis, and diabetes mellitus. This study was undertaken to test the effects of sleep loss on activation of nuclear factor (NF)-kappaB, a transcription factor that serves a critical role in the inflammatory signaling cascade.

Methods

In 14 healthy adults (seven women; seven men), peripheral blood mononuclear cell NF-kappaB was repeatedly assessed, along with enumeration of lymphocyte subpopulations, in the morning after baseline sleep, partial sleep deprivation (awake from 11 pm to 3:00 am), and recovery sleep.

Results

In the morning after a night of sleep loss, mononuclear cell NF-kappaB activation was significant

SUBMITTER: Irwin MR 

PROVIDER: S-EPMC2547406 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature