Live, attenuated influenza virus (LAIV) vehicles are strong inducers of immunity toward influenza B virus.

ABSTRACT: Historically, vaccines developed toward influenza viruses of the B type using methodologies developed for influenza A viruses as a blueprint have not been equally efficacious or effective. Because most influenza research and public attention concerns influenza A viruses, these shortcomings have not been adequately addressed. In this manuscript, we utilized different influenza vaccine vehicles to compare immunogenicity and protection in mice and ferrets after vaccination against an influenza B virus. We report that plasmid DNA vaccines demonstrate low immunogenicity profiles and poor protection compared to either whole, inactivated influenza virus (IIV) or, live, attenuated influenza virus (LAIV) vaccines. When mixed prime:boost regimens using LAIV and IIV were studied, we observed a boosti

SUBMITTER: Huber VC 

PROVIDER: S-EPMC2547490 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature