Finishing touches: post-translational modification of protein factors involved in mammalian pre-mRNA 3' end formation.

ABSTRACT: In eukaryotes, a pre-messenger RNA (pre-mRNA) must undergo several processing reactions before it is exported to the cytoplasm for translation. One of these reactions, endonucleolytic 3' cleavage at the polyadenylation site, prepares the pre-mRNA for addition of the poly(A) tail and defines the 3' untranslated region (UTR), which typically contains important gene expression regulatory sequences. While the protein factors responsible for the endonucleolytic cleavage have been largely identified, the means by which their action is limited to the 3' end of the transcription unit and coordinated with other co-transcriptional events remains unclear. In this review, we summarize and review recent findings revealing that the mammalian 3' cleavage factors undergo extensive post-translational modif

SUBMITTER: Ryan K 

PROVIDER: S-EPMC2548416 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature