Quantitative modeling of currents from a voltage gated ion channel undergoing fast inactivation.

ABSTRACT: Ion channels play a central role in setting gradients of ion concentration and electrostatic potentials, which in turn regulate sensory systems and other functions. Based on the structure of the open configuration of the Kv1.2 channel and the suggestion that the two ends of the N-terminal inactivating peptide form a bivalent complex that simultaneously blocks the channel pore and binds to the cytoplasmic T1 domain, we propose a six state kinetic model that for the first time reproduces the kinetics of recovery of the Drosophila Shaker over the full range of time scales and hyperpolarization potentials, including tail currents. The model is motivated by a normal mode analysis of the inactivated channel that suggests that a displacement consistent with models of the closed state propagates t

SUBMITTER: Camacho CJ 

PROVIDER: S-EPMC2551740 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature