Investigation of the regioselectivity for the staudinger reaction and its application for the synthesis of aminoglycosides with N-1 modification.

ABSTRACT: The criteria for controlling the regioselectivity of Staudinger reduction of azides have been investigated. These findings enable a convenient direct N-1 modification of the perazidoneamine and perazidoribostamycin resulting in the synthesis of aminoglycoside antibiotics with activity against drug-resistant bacteria.

SUBMITTER: Li J 

PROVIDER: S-EPMC2553255 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature