Comparison of algorithms for pre-processing of SELDI-TOF mass spectrometry data.

ABSTRACT:

Motivation

Surface-enhanced laser desorption and ionization (SELDI) time of flight (TOF) is a mass spectrometry technology. The key features in a mass spectrum are its peaks. In order to locate the peaks and quantify their intensities, several pre-processing steps are required. Though different approaches to perform pre-processing have been proposed, there is no systematic study that compares their performance.

Results

In this article, we present the results of a systematic comparison of various popular packages for pre-processing of SELDI-TOF data. We evaluate their performance in terms of two of their primary functions: peak detection and peak quantification. Regarding peak quantification, the performance of the algorithms is measured in terms of reproducibility. For peak

SUBMITTER: Cruz-Marcelo A 

PROVIDER: S-EPMC2553436 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature