A comparative study of survival models for breast cancer prognostication based on microarray data: does a single gene beat them all?

ABSTRACT:

Motivation

Survival prediction of breast cancer (BC) patients independently of treatment, also known as prognostication, is a complex task since clinically similar breast tumors, in addition to be molecularly heterogeneous, may exhibit different clinical outcomes. In recent years, the analysis of gene expression profiles by means of sophisticated data mining tools emerged as a promising technology to bring additional insights into BC biology and to improve the quality of prognostication. The aim of this work is to assess quantitatively the accuracy of prediction obtained with state-of-the-art data analysis techniques for BC microarray data through an independent and thorough framework.

Results

Due to the large number of variables, the reduced amount of samples and the high d

SUBMITTER: Haibe-Kains B 

PROVIDER: S-EPMC2553442 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature