Regulatory hotspots in the malaria parasite genome dictate transcriptional variation.

ABSTRACT: The determinants of transcriptional regulation in malaria parasites remain elusive. The presence of a well-characterized gene expression cascade shared by different Plasmodium falciparum strains could imply that transcriptional regulation and its natural variation do not contribute significantly to the evolution of parasite drug resistance. To clarify the role of transcriptional variation as a source of stain-specific diversity in the most deadly malaria species and to find genetic loci that dictate variations in gene expression, we examined genome-wide expression level polymorphisms (ELPs) in a genetic cross between phenotypically distinct parasite clones. Significant variation in gene expression is observed through direct co-hybridizations of RNA from different P. falciparum clones. Near

SUBMITTER: Gonzales JM 

PROVIDER: S-EPMC2553844 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature