Comparative proteomics approach to screening of potential diagnostic and therapeutic targets for oral squamous cell carcinoma.

ABSTRACT: This work demonstrates that a comprehensive strategy of proteomics identification combined with further validation and detailed functional analysis should be adopted in the field of cancer biomarker discovery. A comparative proteomics approach was utilized to identify differentially expressed proteins in 10 oral squamous carcinoma samples paired with their corresponding normal tissues. A total of 52 significantly and consistently altered proteins were identified with eight of these being reported for the first time in oral squamous carcinoma. Of the eight newly implicated proteins, RACK1 was chosen for detailed analysis. RACK1 was demonstrated to be up-regulated in cancer at both the mRNA and protein levels. Immunohistochemical examination showed that the enhanced expression of RACK1 was c

SUBMITTER: Wang Z 

PROVIDER: S-EPMC2556024 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature