Protein co-evolution, co-adaptation and interactions.

ABSTRACT: Co-evolution has an important function in the evolution of species and it is clearly manifested in certain scenarios such as host-parasite and predator-prey interactions, symbiosis and mutualism. The extrapolation of the concepts and methodologies developed for the study of species co-evolution at the molecular level has prompted the development of a variety of computational methods able to predict protein interactions through the characteristics of co-evolution. Particularly successful have been those methods that predict interactions at the genomic level based on the detection of pairs of protein families with similar evolutionary histories (similarity of phylogenetic trees: mirrortree). Future advances in this field will require a better understanding of the molecular basis of the co-ev

SUBMITTER: Pazos F 

PROVIDER: S-EPMC2556093 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature