Genome signature analysis of thermal virus metagenomes reveals Archaea and thermophilic signatures.

ABSTRACT:

Background

Metagenomic analysis provides a rich source of biological information for otherwise intractable viral communities. However, study of viral metagenomes has been hampered by its nearly complete reliance on BLAST algorithms for identification of DNA sequences. We sought to develop algorithms for examination of viral metagenomes to identify the origin of sequences independent of BLAST algorithms. We chose viral metagenomes obtained from two hot springs, Bear Paw and Octopus, in Yellowstone National Park, as they represent simple microbial populations where comparatively large contigs were obtained. Thermal spring metagenomes have high proportions of sequences without significant Genbank homology, which has hampered identification of viruses and their linkage with hosts. To a

SUBMITTER: Pride DT 

PROVIDER: S-EPMC2556352 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature