Self-assembled DNA nanostructures for distance-dependent multivalent ligand-protein binding.

ABSTRACT: An important goal of nanotechnology is to assemble multiple molecules while controlling the spacing between them. Of particular interest is the phenomenon of multivalency, which is characterized by simultaneous binding of multiple ligands on one biological entity to multiple receptors on another. Various approaches have been developed to engineer multivalency by linking multiple ligands together. However, the effects of well-controlled inter-ligand distances on multivalency are less well understood. Recent progress in self-assembling DNA nanostructures with spatial and sequence addressability has made deterministic positioning of different molecular species possible. Here we show that distance-dependent multivalent binding effects can be systematically investigated by incorporating multipl

SUBMITTER: Rinker S 

PROVIDER: S-EPMC2556356 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature