MetaSim: a sequencing simulator for genomics and metagenomics.

ABSTRACT:

Background

The new research field of metagenomics is providing exciting insights into various, previously unclassified ecological systems. Next-generation sequencing technologies are producing a rapid increase of environmental data in public databases. There is great need for specialized software solutions and statistical methods for dealing with complex metagenome data sets.

Methodology/principal findings

To facilitate the development and improvement of metagenomic tools and the planning of metagenomic projects, we introduce a sequencing simulator called MetaSim. Our software can be used to generate collections of synthetic reads that reflect the diverse taxonomical composition of typical metagenome data sets. Based on a database of given genomes, the program allows the use

SUBMITTER: Richter DC 

PROVIDER: S-EPMC2556396 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature