Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait.

ABSTRACT: Age-related hearing impairment (ARHI), or presbycusis, is a very common multifactorial disorder. Despite the knowledge that genetics play an important role in the etiology of human ARHI as revealed by heritability studies, to date, its precise genetic determinants remain elusive. Here we report the results of a cross-sectional family-based genetic study employing audiometric data. By using principal component analysis, we were able to reduce the dimensionality of this multivariate phenotype while capturing most of the variation and retaining biologically important features of the audiograms. We conducted a genome-wide association as well as a linkage scan with high-density SNP microarrays. Because of the presence of genetic population substructure, association testing was stratified after

SUBMITTER: Huyghe JR 

PROVIDER: S-EPMC2556434 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature