The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research.

ABSTRACT: Technological and scientific advances, stemming in large part from the Human Genome and HapMap projects, have made large-scale, genome-wide investigations feasible and cost effective. These advances have the potential to dramatically impact drug discovery and development by identifying genetic factors that contribute to variation in disease risk as well as drug pharmacokinetics, treatment efficacy, and adverse drug reactions. In spite of the technological advancements, successful application in biomedical research would be limited without access to suitable sample collections. To facilitate exploratory genetics research, we have assembled a DNA resource from a large number of subjects participating in multiple studies throughout the world. This growing resource was initially genotyped with

SUBMITTER: Nelson MR 

PROVIDER: S-EPMC2556436 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature