ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts.

ABSTRACT:

Rationale

Inhaled beta-agonists are one of the most widely used classes of drugs for the treatment of asthma. However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients.

Objectives

To screen variants in candidate genes in the steroid and beta-adrenergic pathways for association with response to inhaled beta-agonists.

Methods

We genotyped 844 single nucleotide polymorphisms (SNPs) in 111 candidate genes in 209 children and their parents participating in the Childhood Asthma Management Program. We screened the association of these SNPs with acute response to inhaled beta-agonists (bronchodilator response [BDR]) usin

SUBMITTER: Litonjua AA 

PROVIDER: S-EPMC2556451 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature