Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis.

ABSTRACT:

Rationale

Polymorphisms affecting Toll-like receptor (TLR)-mediated responses could predispose to excessive inflammation during an infection and contribute to an increased risk for poor outcomes in patients with sepsis.

Objectives

To identify hypermorphic polymorphisms causing elevated TLR-mediated innate immune cytokine and chemokine responses and to test whether these polymorphisms are associated with increased susceptibility to death, organ dysfunction, and infections in patients with sepsis.

Methods

We screened single-nucleotide polymorphisms (SNPs) in 43 TLR-related genes to identify variants affecting TLR-mediated inflammatory responses in blood from healthy volunteers ex vivo. The SNP associated most strongly with hypermorphic responses was tested for associati

SUBMITTER: Wurfel MM 

PROVIDER: S-EPMC2556453 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature