Chronic exposure to ambient levels of urban particles affects mouse lung development.

ABSTRACT:

Rationale

Chronic exposure to air pollution has been associated with adverse effects on children's lung growth.

Objectives

We analyzed the effects of chronic exposure to urban levels of particulate matter (PM) on selected phases of mouse lung development.

Methods

The exposure occurred in two open-top chambers (filtered and nonfiltered) placed 20 m from a street with heavy traffic in São Paulo, 24 hours/day for 8 months. There was a significant reduction of the levels of PM(2.5) inside the filtered chamber (filtered = 2.9 +/- 3.0 microg/m(3), nonfiltered = 16.8 +/- 8.3 microg/m(3); P = 0.001). At this exposure site, vehicular sources are the major components of PM(2.5) (PM

SUBMITTER: Mauad T 

PROVIDER: S-EPMC2556454 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature