Association of radiographic emphysema and airflow obstruction with lung cancer.

ABSTRACT:

Rationale

To study the relationship between emphysema and/or airflow obstruction and lung cancer in a high-risk population.

Objective

We studied lung cancer related to radiographic emphysema and spirometric airflow obstruction in tobacco-exposed persons who were screened for lung cancer using chest computed tomography (CT).

Methods

Subjects completed questionnaires, spirometry, and low-dose helical chest CT. CT scans were scored for emphysema based on National Emphysema Treatment Trial criteria. Multiple logistic regressions estimated the independent associations between various factors, including radiographic emphysema and airflow obstruction, and subsequent lung cancer diagnosis.

Measurements and main results

Among 3,638 subjects, 57.5, 18.8, 14.6, and 9.1% h

SUBMITTER: Wilson DO 

PROVIDER: S-EPMC2556456 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature