Cortical processing of respiratory occlusion stimuli in children with central hypoventilation syndrome.

ABSTRACT:

Rationale

The ability of patients with central hypoventilation syndrome (CHS) to produce and process mechanoreceptor signals is unknown.

Objectives

Children with CHS hypoventilate during sleep, although they generally breathe adequately during wakefulness. Previous studies suggest that they have compromised central integration of afferent stimuli, rather than abnormal sensors or receptors. Cortical integration of afferent mechanical stimuli caused by respiratory loading or upper airway occlusion can be tested by measuring respiratory-related evoked potentials (RREPs). We hypothesized that patients with CHS would have blunted RREP during both wakefulness and sleep.

Methods

RREPs were produced with multiple upper airway occlusions and were obtained during wakefulness, s

SUBMITTER: Huang J 

PROVIDER: S-EPMC2556457 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature