CD28 down-regulation on CD4 T cells is a marker for graft dysfunction in lung transplant recipients.

ABSTRACT:

Rationale

Repeated antigen-driven proliferations cause CD28 on T cells to down-regulate. We hypothesized that alloantigen-induced proliferations could cause CD28 down-regulation in lung transplant recipients.

Objectives

To ascertain if CD28 down-regulation on CD4 T cells associated with manifestations of allograft dysfunction in lung transplant recipients.

Methods

Peripheral blood CD4 T cells from 65 recipients were analyzed by flow cytometry, cytokine multiplex and proliferative assays, and correlated with clinical events.

Measurements and main results

Findings that CD28 was present on less than 90% of total CD4 T cells were predominantly seen among the recipients with bronchiolitis obliterans syndrome (specificity = 88%). Perforin and granzyme B were produced

SUBMITTER: Studer SM 

PROVIDER: S-EPMC2556458 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature