Ontology highlight
ABSTRACT:
SUBMITTER: Salo AM
PROVIDER: S-EPMC2561927 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
American journal of human genetics 20081002 4
Lysyl hydroxylase 3 (LH3, encoded by PLOD3) is a multifunctional enzyme capable of catalyzing hydroxylation of lysyl residues and O-glycosylation of hydroxylysyl residues producing either monosaccharide (Gal) or disaccharide (Glc-Gal) derivatives, reactions that form part of the many posttranslational modifications required during collagen biosynthesis. Animal studies have confirmed the importance of LH3, particularly in biosynthesis of the highly glycosylated type IV and VI collagens, but to da ...[more]