Solution-phase parallel synthesis of a library of delta(2)-pyrazolines.

ABSTRACT: A parallel synthesis of a library (80 members) of 2-pyrazolines in solution phase is described. The 2-pyrazoline core was accessed through the [3 + 2] cycloaddition of nitrilimines with enoyl oxazolidinones. The cycloaddition provided two regioisomers, the major product being the C regioisomer. The oxazolidinone moiety was further reduced to the primary alcohol, producing another library of 5-hydroxymethyl-2-pyrazolines. The Lipinski profiles and calculated ADME properties of the compounds are also reported.

SUBMITTER: Manyem S 

PROVIDER: S-EPMC2562233 | biostudies-literature | 2007 Jan-Feb

REPOSITORIES: biostudies-literature