Total synthesis of enantiopure (+)-gamma-lycorane using highly efficient Pd-catalyzed asymmetric allylic alkylation.

ABSTRACT: [reaction: see text] A highly efficient short total synthesis of (+)-gamma-lycorane (>99% ee, 41% overall yield) was achieved by using the asymmetric allylic alkylation in the key step catalyzed by palladium complexes with novel chiral biphenol-based monodentate phosphoramidite ligands.

SUBMITTER: Chapsal BD 

PROVIDER: S-EPMC2562274 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature