Variations in stress sensitivity and genomic expression in diverse S. cerevisiae isolates.

ABSTRACT: Interactions between an organism and its environment can significantly influence phenotypic evolution. A first step toward understanding this process is to characterize phenotypic diversity within and between populations. We explored the phenotypic variation in stress sensitivity and genomic expression in a large panel of Saccharomyces strains collected from diverse environments. We measured the sensitivity of 52 strains to 14 environmental conditions, compared genomic expression in 18 strains, and identified gene copy-number variations in six of these isolates. Our results demonstrate a large degree of phenotypic variation in stress sensitivity and gene expression. Analysis of these datasets reveals relationships between strains from similar niches, suggests common and unique features of

SUBMITTER: Kvitek DJ 

PROVIDER: S-EPMC2562515 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature