Effects of aneuploidy on genome structure, expression, and interphase organization in Arabidopsis thaliana.

ABSTRACT: Aneuploidy refers to losses and/or gains of individual chromosomes from the normal chromosome set. The resulting gene dosage imbalance has a noticeable affect on the phenotype, as illustrated by aneuploid syndromes, including Down syndrome in humans, and by human solid tumor cells, which are highly aneuploid. Although the phenotypic manifestations of aneuploidy are usually apparent, information about the underlying alterations in structure, expression, and interphase organization of unbalanced chromosome sets is still sparse. Plants generally tolerate aneuploidy better than animals, and, through colchicine treatment and breeding strategies, it is possible to obtain inbred sibling plants with different numbers of chromosomes. This possibility, combined with the genetic and genomics tools av

SUBMITTER: Huettel B 

PROVIDER: S-EPMC2562519 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature