Association of donor inflammation- and apoptosis-related genotypes and delayed allograft function after kidney transplantation.

ABSTRACT:

Background

Delayed renal allograft survival (delayed graft function [DGF]) after deceased donor kidney transplantation is associated with an increased risk of allograft loss. Inflammatory response and apoptosis are associated with increased risk of DGF.

Study design

Cross-sectional study.

Setting & participants

We first recruited 616 recipients of kidneys from 512 deceased kidney donors, and donor DNA was genotyped. These recipients, who were included in a prospective cohort study of 9 transplant centers in the Delaware Valley region, had their DGF outcome obtained through medical record abstraction. We then identified the recipient (n = 349) of the contralateral deceased kidney donor, if not part of the cohort, through the US Renal Data System registry. The final coh

SUBMITTER: Israni AK 

PROVIDER: S-EPMC2562522 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature