Within-subject comparison of the psychopharmacological profiles of oral oxycodone and oral morphine in non-drug-abusing volunteers.

ABSTRACT:

Rationale

Nonmedical use and abuse of prescription opioids is a significant problem in the USA. Little attention has been paid to assessing the relative psychopharmacological profile (including abuse liability-related effects) of specific prescription opioids.

Objectives

The aim of this study is to directly compare the psychopharmacological profile of two oral opioids within the same subject.

Methods

A randomized, placebo-controlled, crossover study was done in which 20 non-drug-abusing volunteers ingested 10 and 20 mg of oxycodone, 30 and 60 mg of morphine, and placebo in separate sessions. Drug doses were equated on an objective measure of opiate effects: miosis. Subjective, psychomotor, reinforcing, and physiological effects of the opioids were assessed.

Results

SUBMITTER: Zacny JP 

PROVIDER: S-EPMC2562738 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature