Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test.

ABSTRACT:

Background

In our previous studies, we reported positive associations between seven ADH4 polymorphisms and substance dependence [i.e., alcohol dependence (AD) and/or drug dependence (DD)] in European-Americans (EAs). In the present study, we address the relationship between ADH4 variation and substance dependence in an African-American (AA) population, and report evidence that supports an association between a different ADH4 polymorphism (rs2226896) and these phenotypes in AAs.

Methods

Two family-based association study methods, i.e., TDT and FBAT, were applied to test the relationship between ADH4 variation and substance dependence in Sample 3 (112 small nuclear families) and in Sample 4 (632 pedigrees), respectively. A population-based case-control association study method

SUBMITTER: Luo X 

PROVIDER: S-EPMC2563013 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature