Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II.

ABSTRACT: Polycomb and trithorax group proteins regulate cellular pluripotency and differentiation by maintaining hereditable states of transcription. Many Polycomb and trithorax group proteins have been implicated in the covalent modification or remodeling of chromatin, but how they interact with each other and the general transcription machinery to regulate transcription is not well understood. The trithorax group protein Kismet-L (KIS-L) is a member of the CHD subfamily of chromatin-remodeling factors that plays a global role in transcription by RNA polymerase II (Pol II). Mutations in CHD7, the human counterpart of kis, are associated with CHARGE syndrome, a developmental disorder affecting multiple tissues and organs. To clarify how KIS-L activates gene expression and counteracts Polycomb group

SUBMITTER: Srinivasan S 

PROVIDER: S-EPMC2563034 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature