Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer.

ABSTRACT: Despite the important role of Th17 cells in the pathogenesis of many autoimmune diseases, their prevalence and the mechanisms by which they are generated and regulated in cancer remain unclear. Here, we report the presence of a high percentage of CD4(+) Th17 cells at sites of ovarian cancer, compared with a low percentage of Th17 cells in peripheral blood mononuclear cells from healthy donors and cancer patients. Analysis of cytokine production profiles revealed that ovarian tumor cells, tumor-derived fibroblasts, and antigen-presenting cells (APCs) secreted several key cytokines including IL-1beta, IL-6, TNF-alpha and TGF-beta, which formed a cytokine milieu that regulated and expanded human IL-17-producing T-helper (Th17) cells. We further show that IL-1beta was critically required for t

SUBMITTER: Miyahara Y 

PROVIDER: S-EPMC2563129 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature