A new locus for autosomal dominant posterior polar cataract in Moroccan Jews maps to chromosome 14q22-23.

ABSTRACT:

Background

Posterior polar cataract is a clinically distinctive opacity located at the back of the lens. It is commonly acquired in age related cataract, and may infrequently occur in pedigrees with congenital cataract. To date, five loci for autosomal dominant congenital posterior polar cataract have been identified. These include two genes, CRYAB and PITX3, on chromosomes 11q and 10q respectively, and three loci with as yet unknown genes on chromosomes 1p, 16q and 20p.

Purpose

To find the chromosomal location of a gene causing autosomal dominant congenital posterior polar cataract in three Moroccan Jewish families.

Methods

A whole genome scan was performed using microsatellite markers spaced at approximately 10 cM intervals. For fine mapping, five additional microsa

SUBMITTER: Pras E 

PROVIDER: S-EPMC2563169 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature