CDH1/E-cadherin germline mutations in early-onset gastric cancer.

ABSTRACT:

Background

Gastric cancer remains a leading cause of cancer deaths worldwide. Genetic factors, including germline mutations in E-cadherin (CDH1, MIM#192090) in hereditary diffuse gastric cancer (HDGC, MIM#137215), are implicated in this disease. Family studies have reported CDH1 germline mutations in HDGC but the role of CDH1 germline mutations in the general population remains unclear.

Aims

To examine the frequency of CDH1 germline mutations in a population-based series of early-onset gastric cancer (EOGC <50 years old).

Methods

211 cases of EOGC were identified in Central-East Ontario region from 1989 to 1993, with archival material and histological confirmation of non-intestinal type gastric cancer available for 81 subjects. Eligible cases were analysed for CDH1 ge

SUBMITTER: Bacani JT 

PROVIDER: S-EPMC2563190 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature