Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European Americans.

ABSTRACT:

Background

The extent which universally common or population-specific alleles can explain between-population variations in phenotypes is unknown. The heritable coronary heart disease risk factor lipoprotein(a) (Lp(a)) level provides a useful case study of between-population variation, as the aetiology of twofold higher Lp(a) levels in African populations compared with non-African populations is unknown.

Objective

To evaluate the association between LPA sequence variations and Lp(a) in European Americans and African Americans and to determine the extent to which LPA sequence variations can account for between-population variations in Lp(a).

Methods

Serum Lp(a) and isoform measurements were examined in 534 European Americans and 249 African Americans from the Choices fo

SUBMITTER: Chretien JP 

PROVIDER: S-EPMC2563202 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature