Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases.

ABSTRACT:

Background

Allergic diseases such as asthma and rhinitis have closely related phenotypes and often occur with atopy. They show strong familial and intra-individual clustering, suggesting overlapping disease aetiology. Various loci and candidate genes have been suggested to underlie allergy. Many or all are still inconclusive. Following genome-wide scans on multiple phenotypes, we previously suggested that chromosome 3q13.12-q21.2 harbours an allergy locus.

Objective

To identify candidate loci in the Danish population, two additional independent sets of sib-pair families were fine-scale mapped in candidate regions showing maximum likelihood scores (MLS) > or =1.5 in the genome-wide scans.

Results

Twenty eight microsatellite markers in a denser map on chromosome 3q were

SUBMITTER: Brasch-Andersen C 

PROVIDER: S-EPMC2563244 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature