A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history.

ABSTRACT:

Background

The EphB2 gene was recently implicated as a prostate cancer (PC) tumour suppressor gene, with somatic inactivating mutations occurring in approximately 10% of sporadic tumours. We evaluated the contribution of EphB2 to inherited PC susceptibility in African Americans (AA) by screening the gene for germline polymorphisms.

Methods

Direct sequencing of the coding region of EphB2 was performed on 72 probands from the African American Hereditary Prostate Cancer Study (AAHPC). A case-control association analysis was then carried out using the AAHPC probands and an additional 183 cases of sporadic PC compared with 329 healthy AA male controls. In addition, we performed an ancestry adjusted association study where we adjusted for individual ancestry among all subjects, in

SUBMITTER: Kittles RA 

PROVIDER: S-EPMC2564535 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature