Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes.

ABSTRACT:

Background

Schizophrenia shows substantial clinical heterogeneity. One common important clinical variable in presentation is the occurrence of episodes of major depression.

Methods

We undertook analyses in an attempt to detect loci that influence susceptibility to, or modify the clinical expression of, schizophrenia according to the occurrence of episodes of major depression. We used a logistic regression framework in which lifetime presence/absence of major depression was entered as a covariate in the linkage analysis of our UK schizophrenia affected sibling pair series (168 affected sibling pairs typed for a 10 cM map of microsatellite markers).

Results

Inclusion of presence/absence of depression as a covariate detected a genome wide significant linkage signal on ch

SUBMITTER: Hamshere ML 

PROVIDER: S-EPMC2564551 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature