High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts.

ABSTRACT:

Background

Recent work suggests that multiple genes and several environmental risk factors influence risk for non-syndromic oral clefts, one of the most common birth defects in humans. Advances in high-throughput genotyping technology now make it possible to test multiple markers in many candidate genes simultaneously.

Methods

We present findings from family based association tests of single nucleotide polymorphism (SNP) markers in 64 candidate genes genotyped using the BeadArray approach in 58 case-parent trios from Maryland (USA) to illustrate how multiple markers in multiple genes can be analysed. To assess whether these genes were expressed in human craniofacial structures relevant to palate and lip development, we also analysed data from the Craniofacial and Oral Gene E

SUBMITTER: Park JW 

PROVIDER: S-EPMC2564555 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature