No associations of human pulmonary tuberculosis with Sp110 variants.

ABSTRACT:

Background

After a recent report on the role of the Ipr1 gene in mediating innate immunity in a mouse model of Mycobacterium tuberculosis infection, the human Ipr1 homologue, Sp110, was considered a promising candidate for an association study in human tuberculosis.

Methods

In a sample of >1000 sputum positive, HIV negative West African patients with pulmonary tuberculosis and >1000 exposed, apparently healthy controls, we have genotyped 21 Sp110 gene variants that were either available from public databases, including HapMap data, or identified by DNA re-sequencing.

Results

No significant differences in the frequencies of any of the 21 variants were observed between patients and controls. This applied also for HapMap tagging variants and the corresponding haplotypes,

SUBMITTER: Thye T 

PROVIDER: S-EPMC2564561 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature